PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats
نویسندگان
چکیده
منابع مشابه
CCR3 expression and function in asthmatic airway smooth muscle cells.
Asthma is characterized by an increase in airway smooth muscle mass and a decreased distance between the smooth muscle layer and the epithelium. Furthermore, there is evidence to indicate that airway smooth muscle cells (ASMC) express a wide variety of receptors involved in the immune response. The aims of this study were to examine the expression of CCR3 on ASMC, to compare this expression bet...
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Jude JA, Solway J, Panettieri RA Jr, Walseth TF, Kannan MS. Differential induction of CD38 expression by TNFin asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 299: L879–L890, 2010. First published August 6, 2010; doi:10.1152/ajplung.00021.2010.—The ADP-ribosyl cyclase activity of CD38, a membrane protein expressed in human airway smooth muscle (ASM) cells, generates cyc...
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Cigarette smoke has been considered a major contributor to the pathogenesis of chronic obstructive pulmonary disease (COPD). In COPD patients, the airway smooth muscle layer has been observed to be markedly thickened and the proliferation of airway smooth muscle cells (ASMCs) was therefore used by the present study as a model to assess the impact of cigarette smoke extract (CSE). ASMCs were exp...
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Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and growth. We have previously described the pattern of isoform expression of PKC in canine airway smooth muscle. This study identified the isoforms present in human cultured airway smooth muscle cells and also addressed the question of whether mitogenesis in these cells is associated with changes in a specifi...
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Carlin, Steve, Kenny X. F. Yang, Richard Donnelly and Judith L. Black. Protein kinase C isoforms in human airway smooth muscle cells: activation of PKC-z during proliferation. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L506–L512, 1999.—Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and growth. We have previously described the pattern of isoform exp...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2008
ISSN: 1671-4083,1745-7254
DOI: 10.1111/j.1745-7254.2008.00795.x